How To Fix: “A Disk Read Error Occurred” – “Error Loading Operating System”

“A Disk Read Error Occurred. Press CTRL+ALT+DEL to restart”

or

“Error Loading Operating System”
This is only one solution because this problem can be caused many reasons.

My symptoms were that I had to restart my computer multiple times after Post-Bios until I could finally start into Windows. Inside Windows, it sometimes locked up when the Hard Drive was under heavy use. I exchanged the cables but it did nothing. Now today I unplugged the Slave Drive and it worked! My Primary Hard Drive (Master) hosts the Operating System and the Secondary Hard Drive (Slave) as a